Certain cycloalkyl imidazopyrimidines, a new class of GABA brain receptor ligands
US5426186A · kind A · utility
7Cited by
3References
34Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Mar 3, 1993 |
| Grant date | Jun 20, 1995 |
| Priority date | — |
| Expiry date | Mar 3, 2013 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61P25/20
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
This invention encompasses compounds of the formula: ##STR1## and pharmaceutically acceptable non-toxic salts thereof wherein: n is 0, 1, or 2, X is ##STR2## and R.sub.1, R.sub.2, R.sub.3, W and Y are variables These compounds are highly selective agonists, antagonists or inverse agonists for GABAa brain receptors or prodrugs thereof and are useful in the diagnosis and treatment of anxiety, sleep, and seizure disorders, overdose with benzodiazepine type drugs, and enhancement of alertness.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.