Nanocrystalline magnetic iron oxide particles-method for preparation and use in medical diagnostics and therapy

US5427767A · kind A · utility

Assignee

• Institut fur Diagnostikforschung GmbH an der Freien Universitat Berlin · DE

Inventors

• Mayk Kresse · Berlin, DE
• Rudiger Lawaczeck · Berlin, DE
• Detlef Pfefferer · Berlin, DE

Key dates

• Filing date: May 13, 1992
• Grant date: Jun 27, 1995
• Expiry date: May 13, 2012

Classification

• Technology area (CPC Y): Emerging Cross-Sectional Technologies
• CPC primary: Y10T436/24
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The invention relates to nanocrystalline magnetic particles consisting of gnetic iron oxide core of Fe.sub.3 O.sub.4, gamma-Fe.sub.2 O.sub.3 or mixtures thereof and an envelope chemisorbed to said core, the method for preparation of these particles as well as the use thereof in medical diagnostics and/or therapy. The magnetic particles, according to the invention, are characterized by composition of the coating material of natural or synthetic glycosaminoglycans and/or their derivatives with molecular weights of 500 Da to 250,000 Da, if necessary, covalently cross-linked with appropriate cross-linking agents and/or modified by specific additives.