Pertussis toxin and use in vaccines
US5427788A · kind A · utility
14Cited by
1References
6Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Jun 17, 1994 |
| Grant date | Jun 27, 1995 |
| Priority date | — |
| Expiry date | Jun 17, 2014 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K39/00
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Cloning and sequencing of the Eco RI fragment of B. pertussis chromosomal DNA with 4696 base pairs, containing the genes which code for the five subunits of the pertussis toxin. A hybrid plasmid containing the DNA fragment or its further fragments and a micro-organism transformed by the hybrid plasmid and capable of expressing the cloned DNA fragment or further fragments thereof by synthesis of the pertussis toxin or one or more subunits of the pertussis toxin. The pertussis toxin or one or more subunits of the pertussis toxin so obtained are useful for the preparation of vaccines and diagnostic kits.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.