Human leukocyte elastase (HLE) inhibitors, and related pharmaceutical compositions and methods of use
US5428021A · kind A · utility
2Cited by
1References
16Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Jan 27, 1994 |
| Grant date | Jun 27, 1995 |
| Priority date | — |
| Expiry date | Jan 27, 2014 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D413/04
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
Novel therapeutic agents useful as inhibitors of HLE are provided. The compounds have the structural formula (I) ##STR1## wherein R.sup.1 through R.sup.9, m, n and p are as defined herein. Methods of using the compounds of formula (I) to inhibit serine proteases and to treat physiological conditions and disease states associated with elevated HLE levels are also provided, as are pharmaceutical compositions containing the compounds.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.