1-(2H-1-oxo-3,4-dihydronaphtyl-6-yl)-acetyl-piperidines as kappa agonists

US5428042A · kind A · utility

Assignee

• Dr Lo Zambeletti S.p.A. · IT

Inventors

• Vittorio Vecchietti · Baranzate, IT
• Roberto Colle · Milano, IT
• Giuseppe Giardina · Milano, IT

Key dates

• Filing date: Dec 23, 1992
• Grant date: Jun 27, 1995
• Expiry date: Dec 23, 2012

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D211/26
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

##STR1## Azacyclic derivatives of formula (I), in which R.sub.1 and R.sub.2 are each linear or branched alkyl, cycloalkyl, cycloalkylalkyl, alkenyl, cycloalkenyl or alkynyl; R.sub.3 and R.sub.4 are identical, and each is a hydrogen or alkyl; and R.sub.5 is hydrogen or alkyl, and their use in medicine are disclosed.