Use of substituted 1,2,4-oxadiazole derivatives for combating endoparasites, new substituted 1,2,4-oxadiazole derivatives, and processes for their preparation

US5428047A · kind A · utility

Assignee

• BAYER HEALTHCARE LLC · DE

Inventors

• Peter Jeschke · Eltville am Rhein, DE
• Werner Lindner · Eppstein, DE
• Achim Harder · Leverkusen, DE
• Norbert Mencke · Leverkusen, DE

Key dates

• Filing date: Sep 21, 1993
• Grant date: Jun 27, 1995
• Expiry date: Sep 21, 2013

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61P33/10
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The present invention relates to the use of substituted 1,2,4-oxadiazole derivatives of the general formula I ##STR1## in which R.sup.1 represents hydrogen, alkyl which is optionally substituted by halogen, alkoxy, hydroxyl, amino, alkylamino, dialkylamino, cycloalkylamino as well as cycloalkyl, optionally substituted aryl or hetaryl, PA1 R.sup.2 represents hydrogen and alkyl, PA1 X represents O, S, SO, SO.sub.2 and N-R.sup.3, PA1 R.sup.3 represents hydrogen, alkyl, alkylcarbonyl or halogenoalkylcarbonyl PA1 R.sup.4 represents identical or different radicals from the series comprising hydrogen, halogen, cyano, nitro, isothiocyanato, amino, aminoacyl, alkylamino, dialkylamino, trialkylammonium halide, sulphonylamino, hydroxyl, mercapto, alkyl, aralkyl, halogenoalkyl, alkoxy, aralkoxy, halogenoalkoxy, aryl, aryloxy, arylthio, arylsulphinyl, arylsulphonyl, alkylthio, halogenoalkylthio, alkylsulphinyl, halogenoalkylsulphinyl, alkylsulphonyl, halogenoalkylsulphonyl, alkoxycarbonyl, alkylcarbonyl, alkylcarbonyloxy, alkoxyalkyl, alkoxyalkoxy, hydroxyalkoxy, hetarylmethyleneoxy, for combating endoparasites in medicine and veterinary medicine, and new compounds of the formula (I) and their …