Bicyclopolyazamacrocyclophosphonic acid complexes for use as radiopharmaceuticals
US5428139A · kind A · utility
42Cited by
13References
10Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Dec 10, 1991 |
| Grant date | Jun 27, 1995 |
| Priority date | — |
| Expiry date | Dec 10, 2011 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K2123/00
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Complexes of bicyclopolyazamacrocyclophosphonic acid compounds with a metal ion, e.g. .sup.153 Sm, .sup.177 Lu, .sup.159 Gd, .sup.149 Pm, .sup.140 La, .sup.175 Yb, .sup.166 Ho, .sup.90 Y, .sup.47 Sc, .sup.186 Re, .sup.188 Re, .sup.142 Pr, .sup.99m Tc, .sup.67 Ga, .sup.68 Ga, .sup.105 Rh, .sup.97 Ru, .sup.111 In, .sup.113m In or .sup.115m In ion, are disclosed. The complexes can be covalently attached to a biologically active molecule, e.g. an antibody or antibody fragment, to form conjugates. The complexes and conjugates are useful as radiopharmaceutical agents for therapy and/or diagnostic purposes.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.