Polymers and oligomers of bile acid derivatives, process for their preparation and their use as pharmaceuticals

US5430116A · kind A · utility

Assignee

• Hoechst GmbH · DE

Inventors

• Werner Kramer · Schwandorf, DE
• Stefan Mullner · Langenfeld, DE
• Matthias Gutweiler · Taunusstein, DE
• Matthias Kroggel · Kelkheim, DE

Key dates

• Filing date: Dec 17, 1992
• Grant date: Jul 4, 1995
• Expiry date: Dec 17, 2012

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C08F20/54
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Polymeric and oligomeric bile acids are described which can be prepared by polymerization of monomeric bile acids of the formula I EQU G--X--A (I) in which G, X and A have the given meanings or by copolymerization with a monomer of the formula IV ##STR1## in which R.sup.9 and R.sup.10 have the given meanings, or by copolymerization with N-vinylpyrrolidone or its derivatives, and/or by copolymerization with ethylenically unsaturated dicarboxylic anhydrides and ethylenically unsaturated dicarboxylic acids each having 2 to 6 carbon atoms; their esters or half esters, alkyl esters having 1-6 carbon atoms, cycloalkyl esters having 5 to 8 carbon atoms, benzyl esters or phenyl esters being understood as esters. They can be used as pharmaceuticals, foodstuff additives, formulation auxiliaries and detergents.