Chrysospermins, active peptides from apiocrea chrysosperma having a pharmacological effect and a use thereof

US5432157A · kind A · utility

Assignee

• Hoechst GmbH · DE

Inventors

• Jorg Metzger · Tübingen, DE
• Brigitte Schlegel · Berlin, DE
• Werner F. Fleck · Erfurt, DE
• Klausjurgen Dornberger · Jena, DE
• Wolfgang Ihn · Jena, DE
• Wolfgang Schade · Jena, DE
• Udo Grafe · Jena, DE

Key dates

• Filing date: Feb 18, 1994
• Grant date: Jul 11, 1995
• Expiry date: Feb 18, 2014

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61K38/00
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The invention relates to the chrysospermin active peptides of the formula I EQU AcPhe-Aib-Ser-Aib-x-Leu-Gln-Gly-Aib-Aib-Ala-Ala-Aib-Pro- y-Aib-Aib-Gln-Trp-ol (SEQ ID NO. 1) in which x and y, independently of each other, denote Aib or Iva, which are synthesized by the fungus Apiocrea chrysosperma during fermentation and which accumulate in the culture broth, to a preparation process, to the use of the chrysospermins as pharmacological active compounds, in particular as active compounds against bacteria, fungi and/or nematodes, and for the treatment of rejection reactions in organ transplantations and of tumor disorders, and to the microorganism Apiocrea chrysosperma DSM 7444.