Haemorheological use of N-alkylated 1,4-dihydropyridine-dicarboxylic acid esters, and some new compounds

US5432185A · kind A · utility

Assignee

• BAYER HEALTHCARE LLC · DE

Inventors

• Otto Behner · Wuppertal, DE
• Hartmut Wollweber · Wuppertal, DE
• Bruno Rosen · Wülfrath, DE
• Siegfried Zaiss · Wuppertal, DE
• Siegfried Goldmann · Wuppertal, DE

Key dates

• Filing date: May 21, 1993
• Grant date: Jul 11, 1995
• Expiry date: May 21, 2013

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61P9/10
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Improving circulation, with minimal effect on blood pressure, using N-alkylated 1,4-dihydropyridines of the formula ##STR1## in which R.sup.1 represents hydrogen, nitro, cyano, trifluoromethyl, trifluoromethoxy, halogen or methyl, PA1 R.sup.2 represents hydrogen, halogen, nitro, hydroxyl, trifluoromethyl or methyl, PA1 R.sup.3 represents hydrogen or cyano, or PA1 R.sup.2 and R.sup.3 together form a fused benzo ring, PA1 R.sup.4 and R.sup.5 are identical or different and represent straight-chain or branched alkyl having up to 8 carbon atoms, which is optionally substituted by alkoxy having up to 4 carbon atoms, and PA1 R.sup.6 represents straight-chain or branched alkyl having up to 10 carbon atoms or represents cycloalkyl having 3 to 7 carbon atoms. Many of the compounds are new.