Fibrinolytic and anti-thrombotic cleavable dimers
US5434073A · kind A · utility
27Cited by
8References
1Claims
0Family size
Assignee
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Key dates
| Filing date | Jun 3, 1992 |
| Grant date | Jul 18, 1995 |
| Priority date | — |
| Expiry date | Jun 3, 2012 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12N2840/107
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Relatively inactive fusion proteins are activatable by enzymes of the clotting cascade to have fibrinolytic and/or clot formation inhibition activity. For example, a fusion protein comprising two hirudin or streptokinase molecules, linked by a cleavable linkage sequence, may be cleaved to yield anti-thrombotic hirudin or fibrinolytic streptokinase by thrombin or Factor Xa. Fibrinolytic or clot formation inhibition activity is therefore directed to the site of clot formation. Cleavable streptokinase/hirudin heterodimers are claimed.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.