Gonadoliberin antagonists

US5434138A · kind A · utility

Assignee

• Hoechst GmbH · DE

Inventors

• Wolfgang Konig · Hofheim, DE
• Jurgen K. Sandow · Königstein, DE
• Cenek Kolar · Marburg, DE

Key dates

• Filing date: Nov 12, 1993
• Grant date: Jul 18, 1995
• Expiry date: Nov 12, 2013

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61K38/00
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Peptides of the formula ##STR1## in which X is alkanoyl, A is optionally substituted D-Nal(2), D-Phe or D-Trp, B is optionally substituted D-Phe, C is D-Pal(3) or optionally substituted D-Phe or D-Trp, and D is Tyr or His, E is D-Ser (R.sup.1), F is Leu, Trp or Phe, G is L-Ser(R.sup.1), H is Gly-NH.sub.2, D-Ala-NH.sub.2 or Azagly-NH.sub.2 and R.sup.1 is a glycosyl radical. These peptides have an inhibitory effect on the formation of the gonadotropins lutropin and follitropin and thus also on the synthesis of testo-sterone and estrogen. A process for the preparation of these peptides is described.