Antimigraine 4-pyrimidinyl and pyridinyl derivatives of indol-3yl-alkylpiperazines

US5434154A · kind A · utility

Assignee

• Bristol-Myers Squibb Company · US

Inventors

• David W. Smith · Richmond, US
• Joseph P. Yevich · Southington, US
• Andrew Williams · Middletown, US
• Edward H. Ruediger · Saint-Lambert, CA
• Keith Combrink · Wallingford, US
• Bradley C. Pearce · East Hampton, US

Key dates

• Filing date: Apr 26, 1994
• Grant date: Jul 18, 1995
• Expiry date: Apr 26, 2014

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D403/12
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

A series of novel alkoxypyridin-4-yl and alkoxypyrimidin-4-yl derivatives of indol-3-ylalkylpiperazines of Formula I are intended to be useful agents ##STR1## for alleviation of vascular headache on the basis of their potent affinity and agonist activity at 5-HT1D binding sites.