Method of targeting a specific location in a body
US5435989A · kind A · utility
9Cited by
19References
35Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Oct 22, 1984 |
| Grant date | Jul 25, 1995 |
| Priority date | — |
| Expiry date | Oct 22, 2004 |
Classification
- Technology area (CPC Y)Emerging Cross-Sectional Technologies
- CPC primaryY10S436/829
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Micellular particles such as small unilamellar vesicles of less than 2000 .ANG. loaded with .sup.111 In are administered to BALB/c mice in which EMT6 tumors had been induced. Whole body scintographs of the mice to which either neutral or positively or negatively charged vesicles had been administered show a substantial quantity of the vesicle entrapped .sup.111 In localized in the tumor. Blocking of macrophages in the liver and spleen by first administering unlabeled, aminomannose substituted vesicles before administration of the labeled vesicles increases uptake of the .sup.111 In labeled vesicles in the tumor.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.