Macrocyclic congugates and their use as diagnostic and therapeutic agents

US5435990A · kind A · utility

Assignee

• THE DOW CHEMICAL COMPANY · US

Inventors

• Roberta C. Cheng · Midland, US
• William A. Fordyce · Midland, US
• William F. Goeckleler · Midland, US
• William J. Kruper, Jr. · Sanford, US
• Richard Keith Frank · Lake Jackson, US
• Joseph R. Garlich · Lake Jackson, US
• Garry E. Kiefer · Lake Jackson, US
• Kenneth McMillan · Lake Jackson, US
• Jaime Simon · Angleton, US
• David A. Wilson · Lake Jackson, US
• Sharon Braughman · Irvine, US

Key dates

• Filing date: Oct 15, 1992
• Grant date: Jul 25, 1995
• Expiry date: Oct 15, 2012

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61K2121/00
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

A group of functionalized macrocyclic polyaminocarboxylate chelants that form complexes with rare earth-type metal ions are disclosed. The complexes, covalently attached to an antibody or antibody fragment, can be used for therapeutic and/or diagnostic purposes for cancer.