Human intra-acrosomal sperm antigen
US5436157A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Feb 16, 1990 |
| Grant date | Jul 25, 1995 |
| Priority date | — |
| Expiry date | Feb 16, 2010 |
Classification
- Technology area (CPC Y)Emerging Cross-Sectional Technologies
- CPC primaryY10S530/852
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
A substantially purified intra-acrosomal human sperm antigen useful in a contraceptive vaccine is disclosed herein. The antigen remains associated with human sperm after the acrosome reaction. In particular, it remains associated with the inner and outer acrosomal membranes. Modified antigens and fragments thereof prepared by protein modification techniques are also disclosed as well as methods for purifying and using the antigens. Also disclosed are monoclonal and polyclonal antibodies to the antigen and methods of making and using such antibodies. Methods of use include purification of the antigen or use in various diagnostic techniques. Also disclosed are cDNA, expression vectors, and transformed microorganisms that produce the antigen.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.