Chemotactic wound healing peptides
US5436228A · kind A · utility
16Cited by
6References
14Claims
0Family size
Inventors
Key dates
| Filing date | Sep 28, 1993 |
| Grant date | Jul 25, 1995 |
| Priority date | — |
| Expiry date | Sep 28, 2013 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K38/00
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Peptides corresponding to an no acid sequences in the C-terminal region of TGF-.beta. are provided. The peptides all contain at least a seven amino acid sequence substantially corresponding to the amino acid sequence of TGF-.beta.1 amino acids 368-374: VYYVGRK, as well as homologs and analogs thereof. The peptides have chemotactic activity towards fibroblasts, monocytes and neutrophils and induce fibroblast proliferation and collagen synthesis. The peptides may be used in compositions and methods for promoting wound healing.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.