Calcification-resistant synthetic biomaterials
US5436291A · kind A · utility
45Cited by
1References
34Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Jan 21, 1994 |
| Grant date | Jul 25, 1995 |
| Priority date | — |
| Expiry date | Jan 21, 2014 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61L2400/02
- WIPO fieldMedical technology
- WIPO sectorInstruments
Abstract
Synthetic biomaterials are provided with irreversibly bound amino diphosphonate, polyphosphonate, or other anticalcification agent to prevent in vivo calcification. Such biomaterials include biocompatible elastomers such as polyurethane and/or polydimethylsiloxane, and the like which are intended for invasive, or in-dwelling use in a human or animal body. Illustratively, reaction conditions utilizing hi-or polyfunctional epoxides result in epoxide bridge incorporation of the anticalcification agent to the biomaterial elastomer.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.