Benzaldehyde intermediates useful in the preparation of 7-oxabicycloheptane carboxylic acid prostaglandin analog anti-thrombotic and anti-vasospastic compounds and method for preparing same
US5436347A · kind A · utility
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Key dates
| Filing date | May 20, 1994 |
| Grant date | Jul 25, 1995 |
| Priority date | — |
| Expiry date | May 20, 2014 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D493/18
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
A method is provided for preparing a chiral benzaldehyde of the structure ##STR1## by acylating an anhydride of the structure ##STR2## with a chiral oxazolidine of the structure ##STR3## where Q is MgHal or Li, and X, Y and Z are as described herein, to form a keto acid which is reduced and cyclized. The resulting benzaldehyde may be used in making the final anti-thrombotic--anti-vasospastic compounds. Novel intermediates are also provided.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.