Process for synthesizing enediynes
US5436361A · kind A · utility
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3References
31Claims
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Key dates
| Filing date | Apr 22, 1994 |
| Grant date | Jul 25, 1995 |
| Priority date | — |
| Expiry date | Apr 22, 2014 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07F7/0805
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
A process for synthesizing enediynes is provided. Specifically, the formed enediynes contain a hex-3-ene-1,5-diynyl group. Production of the enediynes involves adding a base to a propargylic halide in the presence of a chelating agent, which causes a carbenoid coupling-elimination sequence of the propargylic halides. A carbenoid destabilizing agent can also be added to the reaction mixture in order to enhance yield. Acyclic and cyclic enediynes can be synthesized according to this process. The enediynes are useful compounds that can be used in a variety of applications including use in the production of anti-tumor agents.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.