DNA sequence and encoded polypeptide useful in the diagnosis of hepatitis disease
US5437974A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Feb 4, 1992 |
| Grant date | Aug 1, 1995 |
| Priority date | — |
| Expiry date | Feb 4, 2012 |
Classification
- Technology area (CPC Y)Emerging Cross-Sectional Technologies
- CPC primaryY10S436/82
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
A novel cDNA clone, 20E, has been isolated and characterized as encoding a previously unknown polypeptide antigen recognized by antibodies in the serum of certain patients with non-A non-B hepatitis (NANBH). The nucleic acid sequence is not represented in the genome of the Hepatitis C Virus (HCV). Neither is the nucleic acid sequence represented in the human genome. The data suggest that the RNA sequence corresponding to clone 20E is contained within the genome of an external infective agent other than HCV, and therefore may represent an additional etiologic agent or contributing factor to the development of NANBH in human patients. The 20E nucleic acid and corresponding polypeptide and respective variants thereof will be useful in a variety of procedures directed at prevention and diagnosis of NANBH.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.