Composition intended to be used for retarding hair loss and for inducing and stimulating hair growth, containing 2-alkyl-4-aminopyrimidine (or 2,4-dialkylpyrimidine) 3-oxide derivatives and new compounds derived from 2-alkyl-4-aminopyrimidine 3-oxide

US5438058A · kind A · utility

Assignee

• L'Oreal · FR

Inventors

• Didier Dufetel · Chelles, FR
• Francoise Estradier · Paris, FR
• Michel Hocquaux · Paris, FR

Key dates

• Filing date: Apr 1, 1994
• Grant date: Aug 1, 1995
• Expiry date: Apr 1, 2014

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D239/47
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Pharmaceutical or cosmetic composition intended to be used, by topical application, for retarding hair loss and for inducing or stimulating hair growth, containing at least one compound of formula: ##STR1## where: R.sub.1 denotes H or C.sub.1 -C.sub.8 alkyl; PA1 R.sub.2 denotes C.sub.1 -C.sub.8 alkyl or NHR.sub.3, where R.sub.3 denotes H or --COOR.sub.4, where R.sub.4 denotes C.sub.1 -C.sub.4 alkyl; PA1 X denotes ##STR2## --OR.sub.9 or --SR.sub.10 ; R.sub.5 and R.sub.6 denote H, optionally substituted C.sub.1 -C.sub.12 alkyl, or C.sub.2 -C.sub.12 alkenyl, C.sub.3 -C.sub.10 cycloalkyl, aralkyl or aryl, or form, with N, a saturated or unsaturated heterocycle; PA1 R.sub.9 denotes optionally substituted C.sub.1 -C.sub.12 alkyl, or C.sub.2 -C.sub.12 alkenyl, C.sub.3 -C.sub.10 cycloalkyl, C.sub.7 -C.sub.12 aralkyl or phenyl, which may optionally be substituted; PA1 R.sub.10 is identical to R.sub.9 ; and PA1 Y denotes O or OSO.sub.3.sup..crclbar. ; as well as its cosmetically or pharmaceutically acceptable acid addition salts.