Stable porfimer sodium compositions and methods for their manufacture
US5438071A · kind A · utility
113Cited by
5References
7Claims
0Family size
Assignee
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Key dates
| Filing date | Jun 10, 1993 |
| Grant date | Aug 1, 1995 |
| Priority date | — |
| Expiry date | Jun 10, 2013 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61P35/00
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
A storage stable porfimer sodium (polyhematoporphyrin ether/ester) composition useful in the photodynamic therapy of cancer and other conditions is provided. The composition is characterized in that the percentage of ester linked porphyrin oligomers is less than 10% of the composition. Improved processes for preparing such compositions are also provided wherein acetylated hematoporphyrin is treated with alkali for sufficient time and temperature to reduce the amount of porphyrin oligomers joined by ester linkages to less than 10% of the composition.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.