Process for the synthesis [R-(R*-,R*-)]-5-(3-chlorophenyl-3-[2-(3,4-dihydroxyphenyl)-1-methylethyl]- 2
US5438148A · kind A · utility
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Key dates
| Filing date | Sep 20, 1994 |
| Grant date | Aug 1, 1995 |
| Priority date | — |
| Expiry date | Sep 20, 2014 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D263/20
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
The invention is the simultaneous addition of boron tribromide and a solution of [R-(R*,R*)]-5-(3-chlorophenyl-3-[2-(3,4-dimethoxyphenyl)-1-methylethyl]-2- oxazolidinone in methylene chloride to methylene chloride while maintaining a constant ratio of 2.10:1.00 of boron tribromide to the substrate [R-(R*,R*)]-5-(3-chlorophenyl-3-[2-(3,4-dimethoxyphenyl)-1-methylethyl]-2- oxazolidinone at a temperature of -5.degree. C. to 10.degree. C. gives [R-(R*,R*)]-5-(3-chlorophenyl-3-[2-(3,4-hydroxyoxyphenyl)-1-methylethyl]-2 -oxazolidinone in an isolated yield of 86.7% and a purity of 98.7%.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.