Electroporation system with voltage control feedback for clinical applications
US5439440A · kind A · utility
Assignee
Inventor
Key dates
| Filing date | Apr 1, 1993 |
| Grant date | Aug 8, 1995 |
| Priority date | — |
| Expiry date | Apr 1, 2013 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61N1/325
- WIPO fieldMedical technology
- WIPO sectorInstruments
Abstract
A method and apparatus are provided for introducing macromolecules such as genes and pharmacological compounds into cells of a patient for therapeutic purposes. An apparatus for the therapeutic application of electroporation to a portion of the anatomy of a patient, includes adjustably spaced electrodes for generating an electric field at a preselected location within a body of a patient, a sensor for generating a distance signal proportionate to the space between the electrodes, and an electrical signal generator responsive to the distance signal for applying an electric signal to the electrodes for causing the repeated generation of electric fields of a predetermined amplitude and duration forcing the walls of preselected cells in the body portion to be transiently permeable for permitting the macromolecules to enter the preselected cells.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.