Non-infectious HIV particles lacking long terminal repeats

US5439809A · kind A · utility

Assignee

• Connaught Laboratories, Inc. · CA

Inventors

• Joel Haynes · Bozeman, US
• Michel H. Klein · Willowdale, CA
• Benjamin Rovinski · Thornhill, CA
• Shi-Xian Cao · Mississauga, CA

Key dates

• Filing date: Jun 15, 1992
• Grant date: Aug 8, 1995
• Expiry date: Jun 15, 2012

Classification

• Technology area (CPC Y): Emerging Cross-Sectional Technologies
• CPC primary: Y10S977/924
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

An immunogenic HIV retrovirus-like particle which is non-infectious and non-replicating and which is useful as a candidate vaccine component against HIV infection, is produced by genetic engineering. A DNA molecule comprising the HIV genome devoid of long terminal repeats is incorporated into an expression vector, which is introduced into mammalian cells for expression of the HIV retrovirus-like particle.