1,4,10,13-tetraoxa-7,16-diazacyclooctadecane derivatives, pharmaceutical compositions containing them and their use for the removal of toxic metal ions and radioactive isotopes from living organism
US5440031A · kind A · utility
Assignees
Inventors
Key dates
| Filing date | Aug 6, 1993 |
| Grant date | Aug 8, 1995 |
| Priority date | — |
| Expiry date | Aug 6, 2013 |
Classification
- Technology area (CPC Y)Emerging Cross-Sectional Technologies
- CPC primaryY10S424/15
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
The invention relates to partially novel metal complexes, salts and double salts of 1,4,10,13-tetraoxa-7,16-diazacyclooctadecane compounds of the formula (I), ##STR1## wherein Q.sup.1 and Q.sup.2 mean hydrogen or a group of the formula (III), ##STR2## in the groups of the formula (III) the R subtituents independently represent hydrogen, a C.sub.1-5 straight or branched chain alkyl group, a C.sub.2-5 straight or branched chain alkenyl group, phenyl or phenyl-C.sub.1-5 alkyl group, the two latter ones optionally being substituted on their aromatic part by one or more halogen(s), C.sub.1-5 alkyl, C.sub.1-5 alkoxy, cyano or nitro group(s), with the proviso that at least one of Q.sup.1 and Q.sup.2 is other than hydrogen; PA0 Me stands for an alkaline metal or alkaline earth metal or transition metal ion; PA0 q is 0 or 1; PA0 M and N, independently from each other, stand for hydrogen or an alkaline metal, alkaline earth metal or optionally substituted ammonium ion; PA0 m, n and p are integers each being equal to the charge of M, N or Me, respectively; PA0 s and r are, independently from each other, 0, 1, 2, 3 or 4, with the proviso that PA1 (i) r, s and q cannot simultaneously be 0; and …
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.