Acetal or ketal substituted xanthine compounds
US5440041A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Feb 8, 1994 |
| Grant date | Aug 8, 1995 |
| Priority date | — |
| Expiry date | Feb 8, 2014 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D473/20
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
There is disclosed compounds and pharmaceutical compositions having a xanthine core of the formula: ##STR1## wherein each of one or two R is independently ##STR2## wherein n is an integer from about 3 to about 18 forming a hydrocarbon chain, wherein the hydrocarbon chain may have one or more double bonds (preferably in a cis configuration), and may be substituted by a hydroxyl, halo or dimethylamino group and/or interrupted by an oxygen atom. The compounds lower elevated levels of unsaturated, non-arachidonate phosphatidic acid (PA) and diacylglycerol (DAG) derived from said PA within seconds of the primary stimulus and their contact with cells. The modulatory effect depends on the nature of the target cell and the stimulus applied.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.