Metal-interferon-alpha crystals
US5441734A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Feb 25, 1993 |
| Grant date | Aug 15, 1995 |
| Priority date | — |
| Expiry date | Feb 25, 2013 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC30B29/58
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The present invention provides for crystalline zinc-interferon alfa-2 (IFN .alpha.-2) having a monoclinic morphology. The present invention further provides for crystalline cobalt-IFN .alpha.-2, crystalline calcium-IFN .alpha.-2, and crystalline IFN .alpha.-2 having a serum half-life of at least about 12 hours when injected into a primate. The present invention further provides for a method for producing a crystalline IFN .alpha.-2 comprising forming a soluble metal-IFN .alpha.-2 complex, and equilibrating the soluble metal-IFN .alpha.-2 complex in solution with an acetate salt of the metal under conditions that will cause the metal-IFN .alpha.-2 solution to become supersaturated and form crystalline metal-IFN .alpha.-2. The present invention also includes crystalline metal-alfa interferon having monoclinic, plate and needle morphologies.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.