Substituted cyclodextrin sulfates and their uses as growth modulating agents
US5441944A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Sep 18, 1992 |
| Grant date | Aug 15, 1995 |
| Priority date | — |
| Expiry date | Sep 18, 2012 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61L2300/802
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The invention relates to highly water soluble substituted .alpha.-, .beta.- or .gamma.-cyclodextrin sulfates associated with a physiologically acceptable cation. Pathological or otherwise undesirable cell or tissue growth in mammals, including humans, is inhibited by administering thereto (1) a water-soluble substituted cyclodextrin sulfate salt, together with (2) a growth-inhibiting organic compound. The growth-inhibiting compound (2) may be asteroid having no inhibiting effect in the absence of (1), or an organic compound which may be an active growth inhibitor, the action of which is potentiated by (1). The invention provides a method for inhibiting angiogenesis and controlling the growth of tumors as well as treating other diseases and pathological conditions associated with undesired cell or tissue growth, including angiogenesis.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.