Phosphonate derivatives of lipophilic amines
US5441946A · kind A · utility
20Cited by
1References
17Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Apr 14, 1994 |
| Grant date | Aug 15, 1995 |
| Priority date | — |
| Expiry date | Apr 14, 2014 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07F9/65324
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
This invention relates to a class of novel phosphonate derivatives of lipophilic amines which exhibit squalene synthase inhibition properties. More specifically the compounds are bis aryl cycloalkylamino and azacycloalkyl phosphonates. Compounds of this invention reduce levels of serum cholesterol in the body without significantly reducing mevalonic metabolite synthesis. This invention relates also to pharmacological compositions and method of treatment for lowering serum cholesterol levels using the compounds of this invention.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.