1,3,4-benzotraizepin-5(4H)-one derivatives and process for the preparation thereof
US5441948A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Sep 3, 1993 |
| Grant date | Aug 15, 1995 |
| Priority date | — |
| Expiry date | Sep 3, 2013 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07F7/0812
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
The invention relates to racemic or optically active 1,3,4-benzotriazepin-5(4H)-one derivatives, a process for the preparation thereof, pharmaceutical compositions comprising the same, to the use of the said compounds for the treatment of diseases and for the preparation of pharmaceutical compositions containing the said compounds as active agent. The new compounds according to the invention correspond to the general formula (I), ##STR1## wherein R.sup.1 represents hydrogen or straight or branched chain C.sub.1-4 alkyl optionally carrying a pyridyl or a phenyl substituent; PA0 R.sup.2 stands for cyanoimino; PA0 R.sup.3 denotes hydrogen or straight or branched chain C.sub.1-4 alkyl; PA0 R.sup.4 stands for C.sub.1-4 alkyl; and PA0 the dotted line does not represent a valency bond; or PA0 R.sup.2 stands for a group of the formula R.sup.9 R.sup.10 N, wherein PA1 R.sup.9 and R.sup.10 are independently hydrogen or straight or branched chain C.sub.1-10 alkyl, or PA1 R.sup.9 R.sup.10 N together form a 5- to 7-membered heterocyclic group; or PA1 R.sup.9 R.sup.10 N together form a group of the formula N.dbd.C(NR.sup.12 R.sup.13)NH.sub.2, wherein R.sup.12 and R.sup.13 are independently hydrog…
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.