Hydroisoquinoline derivatives
US5441956A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Jan 5, 1994 |
| Grant date | Aug 15, 1995 |
| Priority date | — |
| Expiry date | Jan 5, 2014 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D495/04
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
##STR1## Compounds of formula (I) in which, R is linear or branched alkyl, cycloalkyl, cycloalkylalkyl, alkenyl, aryl, aralkyl or furan-2-yl alkyl; R.sub.1 and R.sub.2, which may be the same or different, are each hydrogen, hydroxy, alkoxy, or halogen; R.sub.3 is hydrogen, hydroxy or alkoxy; "Het" is optionally substituted single or fused heteroxyclic ring, containing from 5 to 10 ring atoms and comprising up to four heteratoms in the or each ring, selected from oxygen, nitrogen and sulphur; R.sub.4 and R.sub.5, which may be the same or different, are each hydrogen alkyl, halogen, nitro; CF, cyano, alkoxy carbonyl, NH, alkylcarbonylamino, hydroxy, alkoxy, or benzyl, are selective delta receptor agonists and are useful in the treatment of pain.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.