Process for the preparation of phosphorus-containing L-amino acids, their derivatives and intermediates for this process
US5442088A · kind A · utility
Assignee
Inventor
Key dates
| Filing date | Jul 7, 1994 |
| Grant date | Aug 15, 1995 |
| Priority date | — |
| Expiry date | Jul 7, 2014 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07F9/3808
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
Process for the preparation of phosphorus-containing L-amino acids, their derivatives and intermediates for this process L-amino acids of the formula I and salts thereof, ##STR1## in which R.sup.1 to R.sup.5 are defined as in claim 1 and n is 0 or 1, are obtained according to the invention by a) reacting an optically active S-homoserine lactone of the formula II, ##STR2## with hydrogen chloride in the presence of an alcohol of the formula R.sup.5 --OH to give novel compounds of the formula III, ##STR3## in which R.sup.3, R.sup.4 and R.sup.5 are defined as in formula I, except that R.sup.5 =H, and b) reacting the resulting compound of formula III with a compound of formula IV, EQU R.sup.1 (O).sub.n -R(OR.sup.2).sub.2 (IV) and if desired, hydrolyzing the product to give a compound of formula I, in which R.sup.5 =H.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.