Enantiomeric resolution
US5442117A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Dec 13, 1993 |
| Grant date | Aug 15, 1995 |
| Priority date | — |
| Expiry date | Dec 13, 2013 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07C209/88
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
A process for obtaining a substantially pure enantiomer of an hydrocarbyl amine is described. The process utilizes first an enantiomerically enriched mixture the of hydrocarbyl amine obtained from kinetic resolution, diastereomeric crystallization or asymmetric synthesis processes. This enriched mixture is reacted with an inorganic acid producing a salt that has the following properties: 1) has at least one eutectic point; 2) a composition that is not at the eutectic point; and 3) a eutectic composition that is closer to the racemic composition than is the eutectic composition of said hydrocarbyl, or be a solid where the salt is a liquid. A substantially pure, enantiomeric salt is separated, leaving a mother liquor comprising the solvent and the hydrocarbyl amine enriched in the other enantiomer.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.