Asymmetric synthesis of (R)- and (S)-arylethanolamines from iminoketones
US5442118A · kind A · utility
10Cited by
2References
13Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Apr 22, 1994 |
| Grant date | Aug 15, 1995 |
| Priority date | — |
| Expiry date | Apr 22, 2014 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07C213/00
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
A method for the enantioselective reduction of an .alpha.-iminoketone to an .alpha.-aminoalcohol is disclosed. The method utilizes a borane reducing agent as the reducing agent and a chiral 1,3,2-oxazaborole as the catalyst. The method is applied to the synthesis of R-albuterol from methyl 5-acetylsalicylate in high yield and high optical purity.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.