Peptide-metal ion pharmaceutical preparation and method

US5443816A · kind A · utility

Assignee

• Rhomed Incorporated · US

Inventors

• Paul O. Zamora · Gaithersburg, US
• Buck A. Rhodes · Albuquerque, US

Key dates

• Filing date: Feb 20, 1992
• Grant date: Aug 22, 1995
• Expiry date: Feb 20, 2012

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61K2123/00
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Peptides containing a biological-function domain and a medically useful metal ion-binding domain are labeled with medically useful metal ions for use in diagnosis and treatment of a variety of pathologic conditions. The peptides have the amino acid sequence PA1 (R.sub.1)-[Y.sub.1 ].sub.n -(R.sub.2), PA1 (R.sub.1)-[Y.sub.1 -(R.sub.2)-Y.sub.1 ].sub.n -(R.sub.3) PA1 and (R.sub.1)-[Y.sub.1 -(R.sub.2)-Y.sub.2 ].sub.n -(R.sub.3) PA1 wherein the medically useful metal ion-binding domain is [Y.sub.1 ].sub.n, [Y.sub.1 -(R.sub.2)-Y.sub.1 ].sub.n or [Y.sub.1 -(R.sub.2)-Y.sub.2 ].sub.n in which n is a number between 1 and about 6 and Y.sub.1 and Y.sub.2 are amino acids with a sulfur, nitrogen or oxygen which is available for binding to metal ions, or can be made available for binding to metal ions; the biological-function domain is an amino acid sequence containing from 1 to about 20 amino acids located in any one or more of R.sub.1, R.sub.2 or R.sub.3 ; and those portions of R.sub.1, R.sub.2 and R.sub.3 which are not part of the biological-function domain are amino acid sequences containing from 0 to about 20 amino acids. The resulting product may be stored frozen or lyophilized, with labelin…