Synthetic polypeptides as inhibitors of HIV-1
US5444044A · kind A · utility
27Cited by
0References
20Claims
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Assignee
Inventors
Key dates
| Filing date | Mar 26, 1992 |
| Grant date | Aug 22, 1995 |
| Priority date | — |
| Expiry date | Mar 26, 2012 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12N2740/16122
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
A synthetic HIV-1-based polypeptide as well as methods for topically inhibiting HIV-1 infectivity or replication. The polypeptide of the present invention has an amino acid sequence substantially corresponding to a specified region of the HIV-1.sub.IIIB virus. The polypeptide of the present invention may be administered in effective amounts for topically inhibiting HIV-1 infectivity or replication. The polypeptide is useful for inhibiting the replication of the HIV-1 virus as well as HIV-1-mediated cytopathogenesis and cell fusion at levels which are within acceptable ranges of cytotoxicity.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.