Aminoalkoxyphenyl derivatives, process for their preparation and compositions containing them

US5444056A · kind A · utility

Assignee

• Sanofi · FR

Inventors

• Jean Gubin · Brussels, BE
• Pierre Chatelain · Brussels, BE
• Henri Inion · Wemmel, BE
• Gilbert Rosseels · Wemmel, BE

Key dates

• Filing date: Feb 7, 1990
• Grant date: Aug 22, 1995
• Expiry date: Feb 7, 2010

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07C2601/14
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

An aminoalkoxyphenyl derivative of general formula: EQU Cy--B--Ph--O--A--Am (1) as well as a pharmaceutically acceptable salt thereof in which PA1 B represents a --S--, --SO-- or --SO.sub.2 -- group, PA1 Ph represents an optionally substituted phenyl radical, PA1 A denotes a straight or branched alkylene radical having from 2 to 5 carbon atoms or a 2-hydroxy propylene radical in which the hydroxy is optionally substituted by a C.sub.1 -C.sub.4 alkyl radical. PA1 Am represents a group: ##STR1## and Cy is a cyclic group, provided that when Cy represents either a benzo[b]furyl group substituted at position 4 by a halogen atom or a C.sub.1 -C.sub.4 alkyl group, or a benzo[b]thienyl group substituted at position 4 by a halogen atom or by a C.sub.1 -C.sub.4 alkyl group and when B represents a --SO.sub.2 -- group, R.sub.3 represents a --Alk--Ar radical.