Platelet derived growth factor antagonists

US5444151A · kind A · utility

Assignee

• LUDWIG INSTITUTE FOR CANCER RESEARCH LTD · GB

Inventors

• Flemming S. Vassbotn · Uppsala, SE
• Maria Andersson · Uppsala, SE
• Gudrun Backstrom · Uppsala, SE
• Ulla Engstrom · Uppsala, SE
• Carl-Henrik Heldin · Uppsala, SE
• Ulf Hellman · Uppsala, SE
• Arne stman · Uppsala, SE
• Bengt Westermark · Uppsala, SE

Key dates

• Filing date: Nov 16, 1992
• Grant date: Aug 22, 1995
• Expiry date: Nov 16, 2012

Classification

• Technology area (CPC Y): Emerging Cross-Sectional Technologies
• CPC primary: Y10S930/12
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The invention describes antagonists for PDGF. The antagonists contain amino acids, and may be monomers or dimers. Especially preferred are dimers which bind the PDGF receptors, but prevent dimerization of the bound receptors. Dimerization is necessary for PDGF effect, hence the antagonistic effect. Also described are nucleic acid sequences for making the antagonists, as well as cell lines transfected with the material.