Enhancement of transdermal delivery with ultrasound and chemical enhancers
US5445611A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Dec 8, 1993 |
| Grant date | Aug 29, 1995 |
| Priority date | — |
| Expiry date | Dec 8, 2013 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61B2018/0047
- WIPO fieldMedical technology
- WIPO sectorInstruments
Abstract
A method of enhancing the permeability of the skin or mucosa to a biologically active permeant or drug is described utilizing ultrasound or ultrasound plus a chemical enhancer. If desired the ultrasound may be modulated by means of frequency modulation, amplitude modulation, phase modulation and/or combinations thereof. A frequency modulation from high to low develops a local pressure gradient directed into the body, thus permitting permeant to traverse the skin or mucosa. The enhanced delivery is preferably accomplished using a chemical enhancer, applying ultrasound optionally at a modulated frequency, amplitude, phase, or combinations thereof that further induces a local pressure gradient into the body. The method is also useful as a means for application of a tattoo by noninvasively delivering a pigment through the skin surface.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.