20-methyl-substituted vitamin D derivatives

US5446035A · kind A · utility

Assignee

• SCHERING CORPORATION · US

Inventors

• Gunter Neef · Berlin, DE
• Andreas Steinmeyer · Berlin, DE
• Gerald Kirsch · Berlin, DE
• Katica Schwarz · Berlin, DE
• Ruth Thieroff-Ekerdt · Concord, US
• Herbert Wiesinger · Berlin, DE
• Martin Haberey · Berlin, DE

Key dates

• Filing date: Sep 16, 1994
• Grant date: Aug 29, 1995
• Expiry date: Sep 16, 2014

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61P43/00
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

New 20-methyl-substituted vitamin D derivatives of general formula I ##STR1## are described in which R.sup.1 means a hydrogen atom, a hydroxy group or an alkanoyloxy group with 1 to 12 carbon atoms or a benzoyloxy group, R.sup.2 means a hydrogen atom or an alkanoyl group with 1 to 12 carbon atoms or a benzoyl group and R.sup.3 means a saturated or unsaturated, straight-chain or branched hydrocarbon radical with up to 18 C atoms, which optionally contains carbocyclic structures, optionally substituted with one or more hydroxy, oxo, amino group(s) and/or one or more halogen atom(s) as well as optionally exhibits one or more oxygen, sulfur and/or nitrogen atom(s) as a bridging link or links in the hydrocarbon radical, and a process for their production. Relative to calcitriol, the new compounds exhibit a greatly improved induction of cell differentiation (HL-60) and are suitable for the production of pharmaceutical agents.