Alpha-helix mimetics and methods relating thereto
US5446128A · kind A · utility
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8Claims
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Assignee
Inventor
Key dates
| Filing date | May 2, 1994 |
| Grant date | Aug 29, 1995 |
| Priority date | — |
| Expiry date | May 2, 2014 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07K14/57545
- WIPO fieldBiotechnology
- WIPO sectorChemistry
Abstract
There are disclosed alpha-helix mimetics and methods relating to the same for imparting or stabilizing alpha-helicity to a peptide or protein. In one aspect, the alpha-helix mimetics contain six- or seven-membered rings covalently attached at the end or within the length of the peptide or protein. The alpha-helix mimetics render the resulting peptide or protein more stable with regard to thermal stability, as well as making the peptide or protein more resistant to proteolytic degredation. In addition, the alpha-helix mimetics may be used in standard peptide synthesis protocols.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.