Process for synthesis of FK-506 and tricarbonyl intermediates
US5446158A · kind A · utility
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Key dates
| Filing date | Oct 12, 1990 |
| Grant date | Aug 29, 1995 |
| Priority date | — |
| Expiry date | Oct 12, 2010 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07C2601/14
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
A process is described for the total synthesis of the macrolide immunosuppressant, FK-506, and important tricarbonyl process intermediates thereof. The tricarbonyl intermediates can be produced by the mild oxidation of 2,3-dihydroxy carboxylate compounds containing olefin moieties.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.