Method of making nanoparticulate X-ray blood pool contrast agents using high molecular weight nonionic surfactants
US5447710A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | May 13, 1994 |
| Grant date | Sep 5, 1995 |
| Priority date | — |
| Expiry date | May 13, 2014 |
Classification
- Technology area (CPC B)Performing Operations; Transporting
- CPC primaryB82Y5/00
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The present invention is directed to a composition comprised of nanoparticles containing an x-ray diagnostic compound, having a high molecular weight nonionic surfactant as a surface modifier adsorbed on the surface thereof and a cloud point modifier associated therewith. The present invention is also directed to a method for making nanoparticles comprising PA0 (i) contacting said nanoparticle containing an x-ray diagnostic compound with a high molecular weight nonionic surfactant for a time and under conditions sufficient to form a nanoparticle with the surfactant adsorbed on the surface thereof; and PA0 (ii) contacting the so treated nanoparticle with a cloud point modifier for a time and under conditions sufficient to form a nanoparticle containing an x-ray diagnostic compound, having a nonionic surfactant as a surface modifier adsorbed on the surface thereof and a cloud point modifier associated therewith. The present invention is still further directed to a method for diagnostic imaging for use in medical procedures comprising administering to the body of a test subject in need of an x-ray an effective contrast producing amount of a composition comprised of nanoparticles conta…
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.