Receptor of the small rhinovirus receptor group
US5447840A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Jan 19, 1994 |
| Grant date | Sep 5, 1995 |
| Priority date | — |
| Expiry date | Jan 19, 2014 |
Classification
- Technology area (CPC Y)Emerging Cross-Sectional Technologies
- CPC primaryY10S530/826
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
A substantially pure receptor with binding activity for rhinoviruses of the small receptor group is disclosed, which has the following characteristics: PA1 (a) a molecular weight of 120 kD on a polyacrylamide gel in the presence of SDS; PA1 (b) a sedimentation constant, determined by sucrose gradient centrifugation in the presence of detergents, corresponding to about 28.4 S; PA1 (c) is bound by Lens culinaris lectin; PA1 (d) is not bound by heparin-sepharose; PA1 (e) is bound irreversibly to an anion exchanger; PA1 (f) has binding activity which is insensitive to neuraminidase; PA1 (g) consists of sub-units connected by intermolecular disulfide bridges; PA1 (h) shows no binding activity to rhinoviruses in the presence of EDTA; and PA1 (i) has a binding activity to rhinoviruses which is only slightly influenced by iodoacetamide. A receptor subunit of the above-described receptor, produced by complete reduction of said receptor, is also disclosed. Multimeric forms of the above-described receptor, obtained by controlled oxidation of the monomeric receptor, are also disclosed. Methods of providing protection against infection by rhinoviruses of the small receptor group with the substa…
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.