Method of resolution of hydroxy substituted cyclopentanone enantiomers using lipase and lithium salt complexation
US5447865A · kind A · utility
6Cited by
5References
17Claims
0Family size
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Key dates
| Filing date | Jan 24, 1994 |
| Grant date | Sep 5, 1995 |
| Priority date | — |
| Expiry date | Jan 24, 2014 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12P7/62
- WIPO fieldBiotechnology
- WIPO sectorChemistry
Abstract
A method for the resolution of optically active compounds from racemic mixtures is provided. In one embodiment of the method, racemic substituted cyclopentenones, useful as eicosanoid intermediates, are enzymatically resolved with lipase and separated by formation of lithium salt complexes. In another embodiment of the method, optically active alcohols are obtained from prochiral halovinyl ketones or alkynyl ketones by selective catalytic reduction with chiral boronic catalysts. In yet another embodiment of the method, prostaglandin E.sub.1 are produced from prostaglandin E.sub.1 esters by selective ester hydrolysis with a lipase.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.