Physical trapping type polymeric micelle drug preparation
US5449513A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Aug 11, 1993 |
| Grant date | Sep 12, 1995 |
| Priority date | — |
| Expiry date | Aug 11, 2013 |
Classification
- Technology area (CPC Y)Emerging Cross-Sectional Technologies
- CPC primaryY10T428/2989
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The present invention relates to drug carriers composed of a block copolymer having hydrophilic and hydrophobic segments, a polymeric micelle type drug comprising hydrophobic drugs trapped by physical treatments in said drug carrier and methods for trapping hydrophobic drugs in the drug carrier. The drugs carrier composed of the block copolymer according to the invention forms a stable polymeric micelle structure with which hydrophobic drugs can be incorporated very efficiently via physical trapping. It was found that the incorporated drug is stably maintained in micelles even in the presence of serum. In addition, a drug difficult to administer into the living body owing to sparing water-solubility for its high hydrophobicity can be administered in the form of polymeric micelle drug.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.