Cycloalkyl amine bis-aryl squalene synthase inhibitors
US5451596A · kind A · utility
14Cited by
7References
22Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Dec 29, 1992 |
| Grant date | Sep 19, 1995 |
| Priority date | — |
| Expiry date | Dec 29, 2012 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07C2601/14
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
This invention relates to a class of novel polycyclic compounds containing a cycloalkyl ring having substituted thereon a primary amine and which is further linked or bridged to two mono- and/or bicyclic rings and which reduces levels of serum cholesterol in the body without significantly reducing mevalonic metabolite synthesis. This invention relates also to pharmacological compositions and method of treatment for lowering serum cholesterol levels using the compounds of this invention.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.