Method for the preparation of a phospholipid-dependent prothrombin activator from the venom of snakes
US5453370A · kind A · utility
8Cited by
8References
5Claims
0Family size
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Key dates
| Filing date | Nov 30, 1992 |
| Grant date | Sep 26, 1995 |
| Priority date | — |
| Expiry date | Nov 30, 2012 |
Classification
- Technology area (CPC G)Physics
- CPC primaryG01N2405/04
- WIPO fieldBiotechnology
- WIPO sectorChemistry
Abstract
A method for the preparation of a phospholipid-dependent prothrombin activator from the venom of snakes belonging to the Elapidae family, the activator comprising an increased plasma clotting activity in the presence of phospholipids and calcium ions; a reduced activity in the presence of Lupus Anticoagulant; an ability to facilitate clotting in a normal clotting time in the presence of platelet poor plasma, the plasma having normal or decreased levels of factor V, VII, VIII, IX, or X; and a major band with a molecular weight of 40,000 to 60,000 daltons on an SDS gel.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.